- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Beta-Amyloid(1-40)
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- Nanjing Peptide Biotech Ltd
- China
- Product Name: β-Amyloid (1-40), rat
- Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
- Purity: 98.0%
- Stocking Period: 7 Day
- Contact: jom
131438-79-4
131438-79-4 structure
- Name: Beta-Amyloid(1-40)
- Chemical Name: amyloid beta-protein (human, 1-40) trifluoroacetate
- CAS Number: 131438-79-4
- Molecular Formula: C194H295N53O58S
- Molecular Weight: 4329.867
- Catalog: Biochemical Peptide
- Create Date: 2018-05-30 08:00:00
- Modify Date: 2024-01-02 13:43:13
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β-Amyloid (1-40) is a primary protein in plaques found in the brains of patients with Alzheimer's disease.
| Name | amyloid beta-protein (human, 1-40) trifluoroacetate |
|---|---|
| Synonyms |
beta Amyloid (1-40) human
β-amyloid 40 Amyloid β-Peptide (1-40) (human) Amyloidb-Peptide(1-40)(human) amyloid β protein fragment 1-40 Abeta(1-40) β-amyloid protein 40 M.W. 4329.86 C194H295N53O58S AMYLOID B-PROTEIN FRAGMENT 1-40 SS-AMYLOID (1-40), RAT aβ40 H-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Gly-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH Abeta40 Human β-amyloid peptide (1-40) β-Amyloid (1-40) |
| Description | β-Amyloid (1-40) is a primary protein in plaques found in the brains of patients with Alzheimer's disease. |
|---|---|
| Related Catalog | |
| In Vitro | β-Amyloid (1-40) and (1-42) are major components of senile plaque amyloids, are physiological peptides present in the brain, cerebrospinal fluid (CSF) and plasma. The levels of CSF β-Amyloid (1-40) and (1-42) show a U-shaped natural course in normal aging[1].Chronic infusion of beta-amyloid (1-40) for 14 days into the rat cerebroventricle decreased the activity of soluble protein kinase C (PKC) in the hippocampus. Subcellular translocation of PKC to membrane fraction in hippocampal slices of rats treated with beta-amyloid (1-40) is completely abolished under acute stimulation with 0.5 microM phorbol-dibutyrate (PDBu)[2]. |
| In Vivo | Chronic infusion of β-Amyloid (1-40) into rat cerebroventricle leads to deficit in spatial and non-spatial memory formation[2]. Chronic treatment of β-Amyloid (1-40) does not change lever-pressing performance significantly, but performance declined significantly 30 days after termination of the chronic daily regimen. The soluble unaggregated form of β-Amyloid (1-40), injected into the dorsal hippocampus, does not appear to have behavioral effects on performance or short-term working memory in rats, but multiple repeat injections produced performance decrements several weeks later. Repeated injection of β-Amyloid (1-40) through indwelling cannulae shows promise for development of an animal model of Alzheimer's disease[3]. |
| Animal Admin | Rats: HPLC buffer insures the β-Amyloid (1-40) does not aggregate in solution prior to injection, β-Amyloid (1-40) and vehicle are bilaterally infused into the hippocampus, 20 min before experimental sessions, in volumes of 1, 2 and 3 μL per side, at a rate of <1 μL/min. Different volumes of the 1 μM solution are used. Volumes (doses) are given in random order and at least three sham-injection sessions are interposed between β-Amyloid (1-40) or vehicle injections. All rats receive all doses of β-Amyloid (1-40) under the acute injection regimen[3]. |
| References |
| Molecular Formula | C194H295N53O58S |
|---|---|
| Molecular Weight | 4329.867 |
| Exact Mass | 4329.155 |
| Appearance | powder | white |
| Storage condition | −20°C |
| Water Solubility | H2O: ~6 mg/mL |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |