612542-14-0

612542-14-0 structure

Name: Hh-Ag1.5
Chemical Name: Hh-Ag1.5
CAS Number: 612542-14-0
Molecular Formula: C₂₈H₂₆ClF₂N₃OS
Molecular Weight: 526.0
Catalog: Signaling Pathways Stem Cell/Wnt Hedgehog
Create Date: 2018-02-22 06:31:49
Modify Date: 2025-11-27 18:42:14
Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM[1]. Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure[2].

Name	Hh-Ag1.5

Description	Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM[1]. Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure[2].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Hedgehog Research Areas >> Metabolic Disease
Target	EC50: 1 nM (Hedgehog)[1]
In Vitro	HhAg1.5 (5 μM; for 3 weeks) facilitates dramatic expansion of quiescent CD133+ CD45- liver stem cells (Hh3A cells) enriched from non-injured liver in vitro[2]. Hh-Ag1.5 competely binds to the Smo-containing membranes with the Ki value of 0.52 nM[3]. The Smo agonist SAG-1.5 displays nanomolar-range potency stimulation of Gli-responsive reporter activity, with an EC50 of 7 nM[4].
References	[1]. Randall W King. Roughing Up Smoothened: Chemical Modulators of Hedgehog Signaling. J Biol. 2002 Nov 6;1(2):8. [2]. Abhisek Mitra, et al. A Small Molecule Hedgehog Agonist HhAg1.5 Mediated Reprogramming Breaks the Quiescence of Noninjured Liver Stem Cells for Rescuing Liver Failure. Transl Res. 2019 Mar;205:44-50. [3]. Maria Frank-Kamenetsky, et al. Small-molecule Modulators of Hedgehog Signaling: Identification and Characterization of Smoothened Agonists and Antagonists. J Biol. 2002 Nov 6;1(2):10. [4]. Cynthia M Rominger, et al. Evidence for Allosteric Interactions of Antagonist Binding to the Smoothened Receptor. J Pharmacol Exp Ther. 2009 Jun;329(3):995-1005.