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8068-28-8

8068-28-8 structure
8068-28-8 structure

Name colistin methanesulfonate sodium salt
Synonyms Colistrimethate sodium
EINECS 232-516-9
MFCD00130824
Colimycin M
Colistimethate sodium
Sodium colistimethate
Colistin sodium methanesulfonate
Colistimethate
Sodium methanesulfonate - N-[(2S)-4-amino-1-{[(2S,3R)-1-{[(2S)-4-amino-1-oxo-1-({(6S,9R,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-diisobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl}amino)-2-butanyl]amino}-3-hydroxy-1-oxo-2-butanyl]amino}-1-oxo-2-butanyl]-6-methyloctanamide (5:5:1)
Description Colistin methanesulfonate sodium salt exhibits MIC values ranged from 4 to 16 mg/liter against susceptible strains (P. aeruginosa)[1].
Related Catalog
In Vitro Colistin methanesulfonate is less bactericidal than colistin at the same multiples of the MIC. Colistin and colistin methanesulfonate are both unequal mixtures of the salts of two components, colistins A and B (1), which may well have different in vitro activities[1].
References

[1]. Jian Li, et al. In Vitro Pharmacodynamic Properties of Colistin and Colistin Methanesulfonate against Pseudomonas aeruginosa Isolates from Patients with Cystic Fibrosis. Antimicrob Agents Chemother. 2001 Mar; 45(3): 781–785.

Molecular Formula C58H115N16Na5O28S5
Molecular Weight 1759.898
Exact Mass 1758.615845
Appearance white to faintly beige
Storage condition 2-8°C
Water Solubility H2O: soluble10mg/mL
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR 3249
WGK Germany 2
RTECS GH1650000