8068-28-8

• 常用中文名：粘菌素甲烷磺酸钠
• 常用英文名：Colistin methanesulfonate sodium salt
• CAS号：8068-28-8
• 分子式：C₅₈H₁₁₅N₁₆Na₅O₂₈S₅
• 分子量：1759.898
• 相关类别： 化学试剂 有机试剂 磺酸盐/亚磺酸盐
• 发布时间：2018-06-11 12:08:23
• 更新时间：2026-06-29 17:30:28
• Colistin methanesulfonate sodium salt对P. aeruginosa 敏感菌类的MIC 值为 4-16 mg/L.

名称

• 中文名: 粘杆菌素甲基磺酸钠
• 英文名: colistin methanesulfonate sodium salt
• 中文别名: 多粘菌素甲磺酸钠; 粘菌素甲磺酸钠/粘菌素甲烷磺酸钠/多粘菌素E甲磺酸钠; 多黏菌素E甲磺酸钠; 甲基磺酸粘杆菌素钠盐; 粘杆菌素甲基磺酸钠,10 MM DMSO 溶液; Colistin Sodium Methanesulfonate 粘杆菌素甲基磺酸钠; 多粘菌素E甲磺酸钠 标准品; COLISTIMETHATE粘杆菌素; 粘菌素甲磺酸钠/粘菌素甲烷磺酸钠/磺粘菌素; 粘菌素甲磺酸钠盐
• 英文别名: COLIMYCIN SODIUM METHANESULFONATE; Colistin, methyl sulfate, sodium salt; Colistimethate sodium; sodiumcolistinmethanesulfonate; COLISTIN SODIUM METHANESULFONATE FROM BA CILLUS COLISTINUS; colistinmethanesulfonicacid,sod; colistinmethanesulfonicacid,sodiumsalt; colistinsulfomethatesodium; EINECS 232-516-9; colimycinm; pentasodium [[4-[[3-hydroxy-1-[[1-[[19-(1-hydroxyethyl)-7,10-bis(2-methylpropyl)-2,5,8,11,14,17,20-htaoxo-4,13,16-tris[2-(sulfonatomethylamino)ethyl]-3,6,9,12,15,18,21-htazacyclotricos-1-yl]amino]-1-oxo-4-(sulfonatomethylamino)butan-2-yl]amino]-1-oxo-butan-2-yl]amino]-3-(6-methyloctanoylamino)-4-oxo-butyl]amino]methanesulfonate; colistimethatesodiumispredfromcolistinbytheactionofformaldehydeandsodiumhydrogensulfitetoformamixtureofditopentabis-sulfomethylatedprimyaminederivatives,mainlypolymyxinse1ande2. Semi-synthetiroductderivedfromafermentationproduct; coly-mycininjectable; E1 Colistimethate sodium for peak identification; ColistimethaleSodium; POLYMYXIN E SODIUM METHANESULFONATE; colymycinm; Colistin Methanesulfonate; Colimycin M; COLISTIN METHANESULFONATE SODIUM; 3a,6-Dimethyl-3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione; First International Standd for Colistin Methane Sulfonate; coly-mycinmpenteral; Colistin methanesulfonate sodium salt, 10 mM in DMSO; Sodium methanesulfonate - N-[(2S)-4-amino-1-{[(2S,3R)-1-{[(2S)-4-amino-1-oxo-1-({(6S,9R,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-diisobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl}amino)-2-butanyl]amino}-3-hydroxy-1-oxo-2-butanyl]amino}-1-oxo-2-butanyl]-6-methyloctanamide (5:5:1); Colistrimethate sodium; colistinsulfomethat; w1929; COLISTIN METHANESULFATE SODIUM; COLISTIN SODIUM METHANESULFONATE; Colistimethate Sodium; colistinsulfomethate; Colistimethate sodium CRS; Colistimethate; Colistimethate sodiumQ: What is Colistimethate sodium Q: What is the CAS Number of Colistimethate sodium Q: What is the storage condition of Colistimethate sodium Q: What e the applications of Colistimethate sodium; Promixi; pentasodium [[4-[[2-hydroxy-1-[[1-[[19-(1-hydroxyethyl)-7,10-diisobutyl-2,5,8,11,14,17,20-htaketo-4,13,16-tris[2-(sulfonatomethylamino)ethyl]-3,6,9,12,15,18,21-htazacyclotricos-1-yl]cbamoyl]-3-(sulfonatomethylamino)propyl]cbamoyl]propyl]amino]-4-keto-3-(6-methyloctanoylamino)butyl]amino]methanesulfonate; (METHANESULFONIC ACID DERIVATIVE OF POLYMYXIN E) SODIUM SALT; colistrimethatesodium; pentasodium [[4-[[3-hydroxy-1-[[1-[[19-(1-hydroxyethyl)-7,10-bis(2-methylpropyl)-2,5,8,11,14,17,20-htaoxo-4,13,16-tris[2-(sulfonatomethylamino)ethyl]-3,6,9,12,15,18,21-htazacyclotricos-1-yl]amino]-1-oxo-4-(sulfonatomethylamino)butan-2-yl]amino]-1-oxobutan-2-yl]amino]-3-(6-methyloctanoylamino)-4-oxobutyl]amino]methanesulfonate; COLISTIN METHANESULFONATE SODIUM SALT; Sodium colistimethate; Colimycin sodium methanesulfonate, Methanesulfonic acid derivative of Polymyxin E, Polymyxin E sodium methanesulfonate; Sodium Colistin Methanesulfonate ( ade); pentasodiumcolistinmethanesulfonate; MFCD00130824; Sodium myxin methanesulfonate; Methanesulfonic acid derivative of Polymyxin E; Coly-mycin M (TN); colistinat; sodiumcolistimethate; COLISTINSULPHOMETHATESODIUM; Colistimethate sodium for peak identification (Y0001888); Colistin sodium methanesulfonate; sodiumcolistinemethanesulfonate

物化性质

• 分子式: C₅₈H₁₁₅N₁₆Na₅O₂₈S₅
• 分子量: 1759.898
• 精确质量: 1758.615845
• 外观性状: white to faintly beige
• 储存条件:

  2-8℃

• 水溶解性: H2O: soluble10mg/mL
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:18

  3.氢键受体数量:33

  4.可旋转化学键数量:39

  5.互变异构体数量:1001

  6.拓扑分子极性表面积749

  7.重原子数量:112

  8.表面电荷:0

  9.复杂度:3430

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:13

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:6

• 更多:

  1. 性状：未确定

  2. 密度（g/mL 25ºC）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC常压）：未确定

  5. 沸点（ºC，常压）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率（n20/D）：未确定

  8. 闪点（ºC，）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值（25℃）：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性(mg/mL) ：未确定

生物活性

• 描述: Colistin methanesulfonate sodium salt对P. aeruginosa 敏感菌类的MIC 值为 4-16 mg/L.
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 体外研究: 在相同的MIC倍数下,甲基磺酸粘杆菌素的杀菌能力比粘菌素低。粘菌素和甲磺酸粘菌素都是粘菌素A和B(1)两种成分盐的不均匀混合物,它们在体外可能有不同的活性[1]。
• 参考文献:

  [1]. Jian Li, et al. In Vitro Pharmacodynamic Properties of Colistin and Colistin Methanesulfonate against Pseudomonas aeruginosa Isolates from Patients with Cystic Fibrosis. Antimicrob Agents Chemother. 2001 Mar; 45(3): 781–785.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: 3249
• WGK德国: 2
• RTECS号: GH1650000