57078-98-5
57078-98-5 structure
- Name: 4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid
- Chemical Name: 4-Maleimidobutyric Acid
- CAS Number: 57078-98-5
- Molecular Formula: C8H9NO4
- Molecular Weight: 183.161
- Catalog: Chemical reagent Organic reagent Aromatic acid
- Create Date: 2018-09-14 11:27:58
- Modify Date: 2026-07-14 19:22:14
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4-Maleimidobutyric acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | 4-Maleimidobutyric Acid |
|---|---|
| Synonyms |
2-Cyclopropyl-5,6,7,8-tetrahydropyrido[4,3-d]pyriMidine hydrochloride
4-MALEIMIDOBUTANOIC ACID Maleimide-(CH2)3-COOH γ-Maleimidobutyric acid, 4-Maleimidobutanoic acid, N-(3-Cboxypropyl)maleimide, N-Maleoyl-4-aminobutyric acid, N-Maleoyl-GABA 4-(2,5-dioxopyrrol-1-yl)butanoic acid MBA 4-Maleimidobutyric acid N-(3-CBOXYPROPYL)MALEIMIDE 2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-butanoic Acid MFCD00043139 MALEIMIDOPROPIONIC ACID 4-MALEIMIDOBUTYRIC ACID GAMMA-MALEIMIDOBUTYRIC ACID 1H-Pyrrole-1-butanoic acid, 2,5-dihydro-2,5-dioxo omega-Maleimidobutyric acid 4-(2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-1-YL)BUTANOIC ACID 4-Maleimidobutyric acid,γ-Maleimidobutyric acid, 4-Maleimidobutanoic acid, N-(3-Cboxypropyl)maleimide, N-Maleoyl-4-aminobutyric acid, N-Maleoyl-GABA 4-MaleimidobutyricAcid> 4-Maleimidobutyric acid(MBA) RECHEM AL CD 0913 4-MaleimidobutyricAci N-MALEOYL-4-AMINOBUTYRIC ACID 4-maleimide butyric acid Mal-(CH2)3-COOH 4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoic acid 2-Cyclopropyl-5,6,7,8-tetrahydropyrido[4,3-d]pyri 4-(2,5-DIOXO-2,5-DIHYDRO-PYRROL-1-YL)-BUTYRIC ACID N-MALEOYL-GABA 4-MALEIMIDOBUTANOIC ACID DIHYDRATE 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-butyric acid |
| Description | 4-Maleimidobutyric acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl-Chain |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 400.1±28.0 °C at 760 mmHg |
| Melting Point | 95-98ºC |
| Molecular Formula | C8H9NO4 |
| Molecular Weight | 183.161 |
| Flash Point | 195.8±24.0 °C |
| Exact Mass | 183.053162 |
| PSA | 74.68000 |
| LogP | 0.40 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.553 |
| Storage condition | 2-8°C |
| Hazard Codes | Xi: Irritant; |
|---|---|
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| WGK Germany | 3 |