443892-56-6

443892-56-6 structure

Name: HDMAPP triammonium
Chemical Name: triammonium [[(E)-4-hydroxy-3-methyl-but-2-enoxy]-oxido-phosphoryl] phosphate
CAS Number: 443892-56-6
Molecular Formula: C₅H₂₁N₃O₈P₂
Molecular Weight: 313.183
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-05-02 13:10:36
Modify Date: 2024-01-10 19:43:03
HDMAPP triammonium is a potent phosphoantigen in the ammonium form and the pyrophosphate form of (E)-HDMAPP. HDMAPP is also a potent activator of γδ T cells and can induce T cell stimulation in vitro (EC50=0.39 nM, TNF-α)[1].

Name	triammonium [[(E)-4-hydroxy-3-methyl-but-2-enoxy]-oxido-phosphoryl] phosphate

Description	HDMAPP triammonium is a potent phosphoantigen in the ammonium form and the pyrophosphate form of (E)-HDMAPP. HDMAPP is also a potent activator of γδ T cells and can induce T cell stimulation in vitro (EC50=0.39 nM, TNF-α)[1].
Related Catalog	Research Areas >> Inflammation/Immunology
Target	TNFRSF1A
In Vitro	HDMAPP triammonium (化合物 3E) (2 μM) 增加原代多克隆人 Vγ9Vδ2 T 细胞中的 TNF-α 释放水平，并具有刺激性生物活性[1]。
In Vivo	HDMAPP triammonium (化合物 3E) (0.02-2.5 mg/kg；静脉注射；15 天) 显着增加食蟹猴模型中的 γδ 细胞[1]。 Animal Model: Nonhuman Primate Model in Cynomolgus[1] Dosage: 0.02 mg/kg, 0.1 mg/kg, 0.5 mg/kg, 2.5 mg/kg Administration: Intravenous injection; once with daily s.c. low doses IL-2 to sustain γδ-T-cell proliferation, for 15 days Result: Significantly increased γδ-cells in vivo at 0.02 mg/kg. Reached maximal effect at 2.5 mg/kg.
References	[1]. Boëdec A, et al. Synthesis and biological activity of phosphonate analogues and geometric isomers of the highly potent phosphoantigen (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate. J Med Chem. 2008 Mar 27;51(6):1747-54.