HDMAPP triammonium
Modify Date: 2024-01-10 19:43:03
HDMAPP triammonium structure
|
Common Name | HDMAPP triammonium | ||
|---|---|---|---|---|
| CAS Number | 443892-56-6 | Molecular Weight | 313.183 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C5H21N3O8P2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HDMAPP triammoniumHDMAPP triammonium is a potent phosphoantigen in the ammonium form and the pyrophosphate form of (E)-HDMAPP. HDMAPP is also a potent activator of γδ T cells and can induce T cell stimulation in vitro (EC50=0.39 nM, TNF-α)[1]. |
| Name | triammonium [[(E)-4-hydroxy-3-methyl-but-2-enoxy]-oxido-phosphoryl] phosphate |
|---|
| Description | HDMAPP triammonium is a potent phosphoantigen in the ammonium form and the pyrophosphate form of (E)-HDMAPP. HDMAPP is also a potent activator of γδ T cells and can induce T cell stimulation in vitro (EC50=0.39 nM, TNF-α)[1]. |
|---|---|
| Related Catalog | |
| Target |
TNFRSF1A |
| In Vitro | HDMAPP triammonium (化合物 3E) (2 μM) 增加原代多克隆人 Vγ9Vδ2 T 细胞中的 TNF-α 释放水平，并具有刺激性生物活性[1]。 |
| In Vivo | HDMAPP triammonium (化合物 3E) (0.02-2.5 mg/kg；静脉注射；15 天) 显着增加食蟹猴模型中的 γδ 细胞[1]。 Animal Model: Nonhuman Primate Model in Cynomolgus[1] Dosage: 0.02 mg/kg, 0.1 mg/kg, 0.5 mg/kg, 2.5 mg/kg Administration: Intravenous injection; once with daily s.c. low doses IL-2 to sustain γδ-T-cell proliferation, for 15 days Result: Significantly increased γδ-cells in vivo at 0.02 mg/kg. Reached maximal effect at 2.5 mg/kg. |
| References |
| Molecular Formula | C5H21N3O8P2 |
|---|---|
| Molecular Weight | 313.183 |
| Exact Mass | 313.080383 |