148892-91-5

148892-91-5 structure

Name: 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM
Chemical Name: Trisodium 5'-O-[({[(hydroxyphosphinato)amino]phosphinato}oxy)phosphinato]guanosine
CAS Number: 148892-91-5
Molecular Formula: C₁₀H₁₄N₆Na₃O₁₃P₃
Molecular Weight: 588.141
Catalog: Signaling Pathways GPCR/G Protein Adenylate Cyclase
Create Date: 2018-04-04 22:51:29
Modify Date: 2024-01-11 17:35:39
Guanylyl Imidodiphosphate (Guanosine 5'-[β,γ-imido]triphosphate) trisodium is a non-hydrolysable GTP analogue, an activator of ADP-ribosylation factor (ARF) and a potent stimulator of adenylate cyclase. Imidodiphosphate trisodium can be used in protein synthesis studies[1][2][3].

Name	Trisodium 5'-O-[({[(hydroxyphosphinato)amino]phosphinato}oxy)phosphinato]guanosine
Synonyms	Guanosine, 5'-O-[hydroxy[[hydroxy(phosphonoamino)phosphinyl]oxy]phosphinyl]-, sodium salt (1:3) Trisodium 5'-O-[({[(hydroxyphosphinato)amino]phosphinato}oxy)phosphinato]guanosine

Description	Guanylyl Imidodiphosphate (Guanosine 5'-[β,γ-imido]triphosphate) trisodium is a non-hydrolysable GTP analogue, an activator of ADP-ribosylation factor (ARF) and a potent stimulator of adenylate cyclase. Imidodiphosphate trisodium can be used in protein synthesis studies[1][2][3].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adenylate Cyclase
In Vitro	Guanylyl Imidodiphosphate trisodium (GppNHp) (100 μM) induces the secretion of dense granules from permeabilized platelets in response to calcium ion stimulation, and GTP-Ral enhances the calcium sensitivity of permeabilized platelet dense granule secretion which is inhibited by Sec5-RBD[1]. Guanylyl Imidodiphosphate trisodium (GppNHp) (0.017-333 μM) causes a significant reduction in the lag time required to stimulate adenylate cyclase activity[3].
References	[1]. Mitsunori Kawato, et al. Regulation of platelet dense granule secretion by the Ral GTPase-exocyst pathway. J Biol Chem. 2008 Jan 4;283(1):166-174. [2]. J Goldberg, et al. Structural basis for activation of ARF GTPase: mechanisms of guanine nucleotide exchange and GTP-myristoyl switching. Cell. 1998 Oct 16;95(2):237-48. [3]. C Gaudin, et al. Overexpression of Gs alpha protein in the hearts of transgenic mice. J Clin Invest. 1995 Apr;95(4):1676-83.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26-36/37
RIDADR	NONH for all modes of transport