191102-87-1

191102-87-1 structure

Name: GGTI-2147
Chemical Name: Methyl N-{4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthyl)benzoyl}-L-leucinate
CAS Number: 191102-87-1
Molecular Formula: C₂₈H₃₀N₄O₃
Molecular Weight: 470.563
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK ROS
Create Date: 2018-03-02 14:29:04
Modify Date: 2025-09-06 10:34:56
GGTI-2147 is a potent GGTase I inhibitor. GGTI-2147 blocks geranyl-geranylation of Rap1A and reduces the activity of Rac1 (one of substrates for GGTI) and ameliorates the OGD/R-induced neuronal apoptosis.GGTI-2147 can be used for neurodevelopmental disorders research, such as autism, depression, and schizophrenia[1].

Name	Methyl N-{4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthyl)benzoyl}-L-leucinate
Synonyms	Methyl N-{4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthyl)benzoyl}-L-leucinate methyl N-{4-[(1H-imidazol-4-ylmethyl)amino]-2-(naphthalen-1-yl)benzoyl}-L-leucinate L-Leucine, N-[4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-, methyl ester

Description	GGTI-2147 is a potent GGTase I inhibitor. GGTI-2147 blocks geranyl-geranylation of Rap1A and reduces the activity of Rac1 (one of substrates for GGTI) and ameliorates the OGD/R-induced neuronal apoptosis.GGTI-2147 can be used for neurodevelopmental disorders research, such as autism, depression, and schizophrenia[1].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS Research Areas >> Neurological Disease
References	[1]. Shangfeng Gao, et al. Astrocyte GGTI-mediated Rac1 prenylation upregulates NF-κB expression and promotes neuronal apoptosis following hypoxia/ischemia. Neuropharmacology. 2016 Apr:103:44-56.