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191102-87-1

191102-87-1 structure
191102-87-1 structure
  • Name: GGTI-2147
  • Chemical Name: Methyl N-{4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthyl)benzoyl}-L-leucinate
  • CAS Number: 191102-87-1
  • Molecular Formula: C28H30N4O3
  • Molecular Weight: 470.563
  • Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK ROS
  • Create Date: 2018-03-02 14:29:04
  • Modify Date: 2024-02-04 10:35:24
  • GGTI-2147 is a potent GGTase I inhibitor. GGTI-2147 blocks geranyl-geranylation of Rap1A and reduces the activity of Rac1 (one of substrates for GGTI) and ameliorates the OGD/R-induced neuronal apoptosis.GGTI-2147 can be used for neurodevelopmental disorders research, such as autism, depression, and schizophrenia[1].

Name Methyl N-{4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthyl)benzoyl}-L-leucinate
Synonyms Methyl N-{4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthyl)benzoyl}-L-leucinate
methyl N-{4-[(1H-imidazol-4-ylmethyl)amino]-2-(naphthalen-1-yl)benzoyl}-L-leucinate
L-Leucine, N-[4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-, methyl ester
Description GGTI-2147 is a potent GGTase I inhibitor. GGTI-2147 blocks geranyl-geranylation of Rap1A and reduces the activity of Rac1 (one of substrates for GGTI) and ameliorates the OGD/R-induced neuronal apoptosis.GGTI-2147 can be used for neurodevelopmental disorders research, such as autism, depression, and schizophrenia[1].
Related Catalog
References

[1]. Shangfeng Gao, et al. Astrocyte GGTI-mediated Rac1 prenylation upregulates NF-κB expression and promotes neuronal apoptosis following hypoxia/ischemia. Neuropharmacology. 2016 Apr:103:44-56.  

Density 1.2±0.1 g/cm3
Boiling Point 710.6±60.0 °C at 760 mmHg
Molecular Formula C28H30N4O3
Molecular Weight 470.563
Flash Point 383.5±32.9 °C
Exact Mass 470.231781
LogP 4.23
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.640