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211439-12-2

211439-12-2 structure
211439-12-2 structure
  • Name: Activity-Dependent Neuroprotective Protein Fragment 74-81, mouse, rat
  • Chemical Name: davunetide
  • CAS Number: 211439-12-2
  • Molecular Formula: C36H60N10O12
  • Molecular Weight: 824.921
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
  • Create Date: 2018-03-28 08:00:00
  • Modify Date: 2024-01-05 22:05:48
  • Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity[1][2][3].
Name davunetide
Synonyms L-Glutamine, L-asparaginyl-L-alanyl-L-prolyl-L-valyl-L-seryl-L-isoleucyl-L-prolyl-
UNII:GF00K3IIWE
davunetide
L-Asparaginyl-L-alanyl-L-prolyl-L-valyl-L-seryl-L-isoleucyl-L-prolyl-L-glutamine
NAPVSIPQ
Description Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity[1][2][3].
Related Catalog
In Vivo Davunetide (2 μg/kg; Intranasally; daily, 5 days a week, for 16 weeks) shows protective effects for central nervous system complications in a diabetes rat model[3]. Animal Model: Male Sprague-Dawley rats (Induced by an i.p. streptozotocin (STZ) injection)[3] Dosage: 2 μg/kg Administration: Intranasally beginning on the day following the STZ injection and were given daily, 5 days a week, for 16 weeks Result: Impaired spatial memory of the diabetic rats was observed in the water maze by attenuated learning curve and worsened performance in the probe memory test. Davunetide treatment significantly improved both measurements.
References

[1]. Quraishe S, et al. NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy. Mol Psychiatry. 2013;18(7):834-842.

[2]. Zhang J, et al. Davunetide improves spatial learning and memory in Alzheimer's disease-associated rats. Physiol Behav. 2017;174:67-73.

[3]. Idan-Feldman A, et al. Davunetide (NAP) as a preventative treatment for central nervous system complications in a diabetes rat model. Neurobiol Dis. 2011;44(3):327-339.
Density 1.3±0.1 g/cm3
Boiling Point 1333.8±65.0 °C at 760 mmHg
Molecular Formula C36H60N10O12
Molecular Weight 824.921
Flash Point 760.5±34.3 °C
Exact Mass 824.439209
LogP -1.78
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.566
Storage condition -20°C

Chemsrc provides CAS#:211439-12-2 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 211439-12-2 | Chemsrc address: https://m.chemsrc.com/en/baike/1462998.html

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