Activity-Dependent Neuroprotective Protein Fragment 74-81, mouse, rat

Modify Date: 2024-01-05 22:05:48

Activity-Dependent Neuroprotective Protein Fragment 74-81, mouse, rat structure	Common Name	Activity-Dependent Neuroprotective Protein Fragment 74-81, mouse, rat
	CAS Number	211439-12-2	Molecular Weight	824.921
	Density	1.3±0.1 g/cm3	Boiling Point	1333.8±65.0 °C at 760 mmHg
	Molecular Formula	C₃₆H₆₀N₁₀O₁₂	Melting Point	N/A
	MSDS	N/A	Flash Point	760.5±34.3 °C

Use of Activity-Dependent Neuroprotective Protein Fragment 74-81, mouse, rat

Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity[1][2][3].

Name	davunetide
Synonym	More Synonyms

Description	Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity[1][2][3].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Research Areas >> Neurological Disease
In Vivo	Davunetide (2 μg/kg; Intranasally; daily, 5 days a week, for 16 weeks) shows protective effects for central nervous system complications in a diabetes rat model[3]. Animal Model: Male Sprague-Dawley rats (Induced by an i.p. streptozotocin (STZ) injection)[3] Dosage: 2 μg/kg Administration: Intranasally beginning on the day following the STZ injection and were given daily, 5 days a week, for 16 weeks Result: Impaired spatial memory of the diabetic rats was observed in the water maze by attenuated learning curve and worsened performance in the probe memory test. Davunetide treatment significantly improved both measurements.
References	[1]. Quraishe S, et al. NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy. Mol Psychiatry. 2013;18(7):834-842. [2]. Zhang J, et al. Davunetide improves spatial learning and memory in Alzheimer's disease-associated rats. Physiol Behav. 2017;174:67-73. [3]. Idan-Feldman A, et al. Davunetide (NAP) as a preventative treatment for central nervous system complications in a diabetes rat model. Neurobiol Dis. 2011;44(3):327-339.

Density	1.3±0.1 g/cm3
Boiling Point	1333.8±65.0 °C at 760 mmHg
Molecular Formula	C₃₆H₆₀N₁₀O₁₂
Molecular Weight	824.921
Flash Point	760.5±34.3 °C
Exact Mass	824.439209
LogP	-1.78
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.566
Storage condition	-20°C