1235449-52-1

1235449-52-1 structure

Name: PI3Kα inhibitor 1
Chemical Name: N-Hydroxy-2-[methyl({2-[6-(methylamino)-3-pyridinyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl}methyl)amino]-5-pyrimidinecarboxamide
CAS Number: 1235449-52-1
Molecular Formula: C₂₃H₂₅N₉O₃S
Molecular Weight: 507.568
Catalog: Research Areas Cancer
Create Date: 2018-06-03 13:22:09
Modify Date: 2025-08-22 22:40:00
PI3Kα inhibitor 1 is a selective PI3Kα inhibitor extracted from patent US/20120088764A1, Compound 243, has an IC50<0.1 μM, PI3Kα inhibitor 1 also inhibits HDAC (0.1 μM≤IC50≤1 μM) .

Name	N-Hydroxy-2-[methyl({2-[6-(methylamino)-3-pyridinyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl}methyl)amino]-5-pyrimidinecarboxamide
Synonyms	N-Hydroxy-2-[methyl({2-[6-(methylamino)-3-pyridinyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl}methyl)amino]-5-pyrimidinecarboxamide 5-Pyrimidinecarboxamide, N-hydroxy-2-[methyl[[2-[6-(methylamino)-3-pyridinyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]amino]- CUDC-908 PI3Kα inhibitor 1 BEBT-908

Description	PI3Kα inhibitor 1 is a selective PI3Kα inhibitor extracted from patent US/20120088764A1, Compound 243, has an IC50<0.1 μM, PI3Kα inhibitor 1 also inhibits HDAC (0.1 μM≤IC50≤1 μM) .
Related Catalog	Research Areas >> Cancer
Target	PI3Kα:0.1 μM (IC50) HDAC:0.1 μM (IC50)
References	[1]. Cai Xiong, et al. Deazapurines, thienopyrimidines and furopyrimidines as phosphoinositide 3-kinase inhibitors with a zinc binding moiety and their preparation and use in the treatment of diseases. From U.S. Pat. Appl. Publ. (2012), US 20120088764 A1 20120412.