1357920-84-3
1357920-84-3 structure
- Name: Belizatinib
- Chemical Name: belizatinib
- CAS Number: 1357920-84-3
- Molecular Formula: C33H44FN5O3
- Molecular Weight: 577.733
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK ALK
- Create Date: 2018-08-24 14:15:46
- Modify Date: 2024-01-08 13:31:04
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Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.
| Name | belizatinib |
|---|---|
| Synonyms |
4-Fluoro-N-(6-{[4-(2-hydroxy-2-propanyl)-1-piperidinyl]methyl}-1-[cis-4-(isopropylcarbamoyl)cyclohexyl]-1H-benzimidazol-2-yl)benzamide
belizatinib Benzamide, 4-fluoro-N-[6-[[4-(1-hydroxy-1-methylethyl)-1-piperidinyl]methyl]-1-[cis-4-[[(1-methylethyl)amino]carbonyl]cyclohexyl]-1H-benzimidazol-2-yl]- TSR-011 |
| Description | Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.7 nM (ALK)[1] |
| In Vitro | TSR-011 has antitumour activity in the clinical trials. |
| In Vivo | TSR-011 exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C33H44FN5O3 |
| Molecular Weight | 577.733 |
| Exact Mass | 577.342834 |
| LogP | 3.99 |
| Index of Refraction | 1.631 |
| Storage condition | -20℃ |
| Hazard Codes | N |
|---|