Belizatinib
Modify Date: 2025-08-25 14:01:59
Belizatinib structure
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Common Name | Belizatinib | ||
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| CAS Number | 1357920-84-3 | Molecular Weight | 577.733 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C33H44FN5O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BelizatinibBelizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase. |
| Name | belizatinib |
|---|---|
| Synonym | More Synonyms |
| Description | Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase. |
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| Related Catalog | |
| Target |
IC50: 0.7 nM (ALK)[1] |
| In Vitro | TSR-011 has antitumour activity in the clinical trials. |
| In Vivo | TSR-011 exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C33H44FN5O3 |
| Molecular Weight | 577.733 |
| Exact Mass | 577.342834 |
| LogP | 3.99 |
| Index of Refraction | 1.631 |
| InChIKey | WSTUJEXAPHIEIM-UHFFFAOYSA-N |
| SMILES | CC(C)NC(=O)C1CCC(n2c(NC(=O)c3ccc(F)cc3)nc3ccc(CN4CCC(C(C)(C)O)CC4)cc32)CC1 |
| Storage condition | -20℃ |
| Hazard Codes | N |
|---|
| 4-Fluoro-N-(6-{[4-(2-hydroxy-2-propanyl)-1-piperidinyl]methyl}-1-[cis-4-(isopropylcarbamoyl)cyclohexyl]-1H-benzimidazol-2-yl)benzamide |
| belizatinib |
| Benzamide, 4-fluoro-N-[6-[[4-(1-hydroxy-1-methylethyl)-1-piperidinyl]methyl]-1-[cis-4-[[(1-methylethyl)amino]carbonyl]cyclohexyl]-1H-benzimidazol-2-yl]- |
| TSR-011 |