1005264-47-0

1005264-47-0 structure

Name	MX69
Synonyms	MX-69 E1/E2/E3 Enzyme,inhibit,E3 ligating enzyme,MX 69,Ubiquitin ligase,IAP,MX69,E1 activating enzyme,E2 conjugating enzyme,Ubiquitin conjugating enzyme,MX-69,Inhibitor,Ubiquitin activating enzyme,MDM-2/p53 4-(8-(N-(3,4-Dimethylphenyl)sulfamoyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl)benzoic acid MX69 ，S8403 Benzoic acid, 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl] MX69 (MX 69 MX69, 10 mM in DMSO

Description	MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment.
Related Catalog	Signaling Pathways >> Apoptosis >> IAP Signaling Pathways >> Apoptosis >> MDM-2/p53 Research Areas >> Cancer
In Vitro	MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro[1].
In Vivo	MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo[1].
References	[1]. Gu L, et al. Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Cancer Cell. 2016 Oct 10;30(4):623-636