2162962-69-6
2162962-69-6 structure
- Name: CU-CPT-9a
- Chemical Name: CU-CPT-9a
- CAS Number: 2162962-69-6
- Molecular Formula: C16H13NO2
- Molecular Weight: 251.28
- Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
- Create Date: 2018-11-10 16:34:06
- Modify Date: 2024-01-10 14:41:22
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CU-CPT-9b is a specific TLR8 antagonist, with an IC50 of 0.7 nM.
| Name | CU-CPT-9a |
|---|---|
| Synonyms | CPD1577 |
| Description | CU-CPT-9b is a specific TLR8 antagonist, with an IC50 of 0.7 nM. |
|---|---|
| Related Catalog | |
| Target |
TLR8:0.7 nM (IC50) |
| In Vitro | CU-CPT-9b is a specific TLR8 antagonist, with an IC50 of 0.7±0.2 nM. ITC experiments have confirmed the strong binding of CU-CPT-9b with a Kd of 21 nM. It is shown that CU-CPT-9b binds to the inactive TLR8 dimer in a similar way to CU-CPT8m. CU-CPT9b utilizes hydrogen bonds with G351 and V520*, which are conserved among TLR8/antagonist structures. Additionally, CU-CPT-9b forms water-mediated contacts with S516* and Q519*, which are not observed in TLR8/CU-CPT8m structure, suggesting that the enhanced potency of CU-CPT-9b derives from the new interactions with these polar residues. The orientation of Y567* also changes to facilitate van der Waals interactions with CU-CPT-9b as compared to TLR8/CU-CPT8m[1]. |
| References |
| Molecular Formula | C16H13NO2 |
|---|---|
| Molecular Weight | 251.28 |
| Storage condition | 2-8℃ |