CU-CPT-9a

Modify Date: 2024-01-10 14:41:22

CU-CPT-9a Structure
CU-CPT-9a structure
 Common Name CU-CPT-9a
CAS Number 2162962-69-6 Molecular Weight 251.28
Density N/A Boiling Point N/A
Molecular Formula C16H13NO2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CU-CPT-9a


CU-CPT-9b is a specific TLR8 antagonist, with an IC50 of 0.7 nM.

 Names

Name CU-CPT-9a
Synonym More Synonyms

 CU-CPT-9a Biological Activity

Description CU-CPT-9b is a specific TLR8 antagonist, with an IC50 of 0.7 nM.
Related Catalog
Target

TLR8:0.7 nM (IC50)

In Vitro CU-CPT-9b is a specific TLR8 antagonist, with an IC50 of 0.7±0.2 nM. ITC experiments have confirmed the strong binding of CU-CPT-9b with a Kd of 21 nM. It is shown that CU-CPT-9b binds to the inactive TLR8 dimer in a similar way to CU-CPT8m. CU-CPT9b utilizes hydrogen bonds with G351 and V520*, which are conserved among TLR8/antagonist structures. Additionally, CU-CPT-9b forms water-mediated contacts with S516* and Q519*, which are not observed in TLR8/CU-CPT8m structure, suggesting that the enhanced potency of CU-CPT-9b derives from the new interactions with these polar residues. The orientation of Y567* also changes to facilitate van der Waals interactions with CU-CPT-9b as compared to TLR8/CU-CPT8m[1].
References

[1]. Zhang S, et al. Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat Chem Biol. 2018 Jan;14(1):58-64.

 Chemical & Physical Properties

Molecular Formula C16H13NO2
Molecular Weight 251.28
Storage condition 2-8℃

 Synonyms

CPD1577
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Chemsrc provides CU-CPT-9a(CAS#:2162962-69-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of CU-CPT-9a are included as well.>> amp version: CU-CPT-9a

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