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  • Product Name: CCX-354
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1010073-75-2

1010073-75-2 structure
1010073-75-2 structure
  • Name: CCR1 antagonist 1
  • Chemical Name: CCR1 antagonist 1
  • CAS Number: 1010073-75-2
  • Molecular Formula: C22H22ClN7O2
  • Molecular Weight: 451.909
  • Catalog: Research Areas Inflammation/Immunology
  • Create Date: 2018-05-15 23:08:03
  • Modify Date: 2024-01-04 13:26:24
  • CCR1 antagonist 1 is an antagonist of CCR1, with anti-inflammatory activity.

Name CCR1 antagonist 1
Synonyms 1-[4-(4-Chloro-3-methoxyphenyl)-1-piperazinyl]-2-[3-(1H-imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]ethanone
Ethanone, 1-[4-(4-chloro-3-methoxyphenyl)-1-piperazinyl]-2-[3-(1H-imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]-
22PQS5K5TY
CCX-354
Description CCR1 antagonist 1 is an antagonist of CCR1, with anti-inflammatory activity.
Related Catalog
Target

CCR1

In Vitro CCR1 antagonist 1 shows potent activities in the chemotaxis assay, with IC50 < 100 nM[1].
In Vivo In vivo, CCR1 antagonist 1 has in vivo anti-inflammatory activity and has superior pharmacokinetic properties[1].
References

[1]. Compounds for the treatment of osteoporosis and cancers. US 20100113472 A1

Density 1.5±0.1 g/cm3
Boiling Point 778.4±60.0 °C at 760 mmHg
Molecular Formula C22H22ClN7O2
Molecular Weight 451.909
Flash Point 424.6±32.9 °C
Exact Mass 451.152344
LogP 1.24
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.724