1423715-37-0
1423715-37-0 structure
- Name: Seclidemstat
- Chemical Name: Seclidemstat
- CAS Number: 1423715-37-0
- Molecular Formula: C20H23ClN4O4S
- Molecular Weight: 450.939
- Catalog: Signaling Pathways Epigenetics Histone Demethylase
- Create Date: 2018-01-15 07:16:08
- Modify Date: 2024-01-08 14:33:14
-
Seclidemstat (SP-2577) is a potent LSD1 inhibitor, with a mean IC50 of 127 nM.
| Name | Seclidemstat |
|---|---|
| Synonyms |
N'-[(1E)-1-(5-Chloro-2-hydroxyphenyl)ethylidene]-3-[(4-methyl-1-piperazinyl)sulfonyl]benzohydrazide
TYH386V3WJ Benzoic acid, 3-[(4-methyl-1-piperazinyl)sulfonyl]-, 2-[(1E)-1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazide |
| Description | Seclidemstat (SP-2577) is a potent LSD1 inhibitor, with a mean IC50 of 127 nM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 127 nM (LSD1)[1] |
| In Vivo | Seclidemstat (Compound 2577) reduces tumor volume at 40, 80 mg/kg by i.p. and also shows such effect at 80 mg/kg via p.o. dosing. |
| References |
[1]. SUBSTITUTED BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS. WO/2017/004519 A1 |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C20H23ClN4O4S |
| Molecular Weight | 450.939 |
| Exact Mass | 450.112854 |
| LogP | 4.07 |
| Index of Refraction | 1.645 |
| Storage condition | 2-8℃ |