Shanghai Nianxing Industrial Co., Ltd
China
Product Name: MutantIDH1inhibitor
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

DC Chemicals Limited
China
Product Name: Mutant Idh1 Inhibitor
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao

1429180-08-4

1429180-08-4 structure

1429180-08-4 structure

Name: Mutant IDH1 inhibitor
Chemical Name: Mutant IDH1 inhibitor
CAS Number: 1429180-08-4
Molecular Formula: C₂₅H₃₄N₆O₃
Molecular Weight: 466.576
Catalog: Signaling Pathways Metabolic Enzyme/Protease Isocitrate Dehydrogenase (IDH)
Create Date: 2018-05-08 10:46:06
Modify Date: 2024-01-02 13:04:50
Mutant IDH1 inhibitor is a potent mutant IDH1 R132H inhibitor with IC50 of < 72 nM.

Name	Mutant IDH1 inhibitor
Synonyms	(4S)-3-(2-{[(1S)-1-{4-[(4-Acetyl-1-piperazinyl)methyl]phenyl}ethyl]amino}-4-pyrimidinyl)-4-isopropyl-1,3-oxazolidin-2-one 2-Oxazolidinone, 3-[2-[[(1S)-1-[4-[(4-acetyl-1-piperazinyl)methyl]phenyl]ethyl]amino]-4-pyrimidinyl]-4-(1-methylethyl)-, (4S)-

Description	Mutant IDH1 inhibitor is a potent mutant IDH1 R132H inhibitor with IC50 of < 72 nM.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Isocitrate Dehydrogenase (IDH) Research Areas >> Cancer
Target	IC50: < 72 nM (mutant IDH1 R132H)
In Vitro	Mutant IDH1 inhibitor is a potent IDH1 R132H inhibitor, and used for the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer[1].
Cell Assay	Day 1: cells are seeded in 384-well plates in triplicates for both the cell proliferation and 2HG assay, and incubated at 37°C, 95% Rh, 5% CO2 overnight. Day 2: compounds are serially diluted 1 :3 (10 point dilution from 10 mM solutions in DMSO) and delivered to the cell assay plates via acoustic dispenser, with final concentration ranging from 30 μM to 1.5 nM. The plates are returned to the incubator after treatment and incubated for 48 hours. Day 4 Proliferation assay: CTG is added to the assay plates and luminescence signal is read on the plate reader. Day 4 2HG assay : Extraction sample preparation consisted of aspirating all media from the assay plates, adding 70 μL of 90% methanol in water, dry ice incubation for 15 minutes, centrifuging at 2000 rpm for 30 min to ensure all particulates have settled, and transferring 30 μL of the supernatant into LC-MS ready plates. LC-MS analysis follows.
References	[1]. 3-Pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH and their preparation. Patent WO 2013046136 A1 20130404

Density	1.2±0.1 g/cm3
Boiling Point	651.8±65.0 °C at 760 mmHg
Molecular Formula	C₂₅H₃₄N₆O₃
Molecular Weight	466.576
Flash Point	348.0±34.3 °C
Exact Mass	466.269226
LogP	2.31
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.608
Storage condition	2-8℃