1448189-80-7
1448189-80-7 structure
- Name: Protein degrader 1 hydrochloride
- Chemical Name: Protein degrader 1 hydrochloride
- CAS Number: 1448189-80-7
- Molecular Formula: C22H31ClN4O3S
- Molecular Weight: 467.025
- Catalog: Signaling Pathways PROTAC PROTAC
- Create Date: 2018-04-27 07:16:16
- Modify Date: 2025-08-25 22:57:49
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Protein degrader 1 hydrochloride is used in the synthesis of HaloPROTACs.
| Name | Protein degrader 1 hydrochloride |
|---|---|
| Synonyms |
3-Methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide hydrochloride (1:1)
L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-, hydrochloride (1:1) MDK-7526 ULM-1 |
| Description | Protein degrader 1 hydrochloride is used in the synthesis of HaloPROTACs. |
|---|---|
| Related Catalog | |
| In Vitro | Small molecule-induced protein degradation is an attractive strategy for the development of chemical probes.Protein degraders have the power to abrogate all of the functions of a drug target at once, including scaffolding functions which are difficult to target with small molecule inhibitors. A novel class of PROTACs that incorporate small molecule VHL ligands to successfully degrade HaloTag7 fusion proteins is developed. HaloPROTACs will inspire the development of future PROTACs with more drug-like properties. In HEK 293 cellsstably expressing GFP-HaloTag7,24 hour treatment with HaloPROTAC1 leads to less than 20% degradation, the longer HaloPROTAC2 leads to nearly 70% degradation of GFP-Halotag7 at 2.5 μM.HaloPROTACs containing protein degrader 1 leads to nearly 70% degradation of GFP-HaloTag7, when sufficiently long linkers are used[1]. |
| References |
| Molecular Formula | C22H31ClN4O3S |
|---|---|
| Molecular Weight | 467.025 |
| Exact Mass | 466.180542 |
| Storage condition | 2-8℃ |