190967-35-2

190967-35-2 structure

Name: RWJ 63556
Chemical Name: RWJ 63556
CAS Number: 190967-35-2
Molecular Formula: C₁₁H₁₀FNO₃S₂
Molecular Weight: 287.330
Catalog: Signaling Pathways Metabolic Enzyme/Protease 5-Lipoxygenase
Create Date: 2018-05-25 21:29:46
Modify Date: 2024-01-07 08:40:13
RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities.

Name	RWJ 63556
Synonyms	Methanesulfonamide, N-[5-(4-fluorophenoxy)-2-thienyl]- N-[5-(4-Fluorophenoxy)-2-thienyl]methanesulfonamide

Description	RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase Research Areas >> Inflammation/Immunology
Target	COX-2 5-Lipoxygenase
In Vitro	RWJ 63556 is a potent inhibitor of leukocyte influx over a period of 24 hr and maintains its in vitro profile on eicosanoids[1].
In Vivo	RWJ 63556 (1 mg/kg, i.v.) significantly inhibits the development of SP-induced oedema[2].
References	[1]. Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101. [2]. Le Filliatre G, et al. Cyclo-oxygenase and lipoxygenase pathways in mast cell dependent-neurogenic inflammation induced by electrical stimulation of the rat saphenous nerve. Br J Pharmacol. 2001 Apr;132(7):1581-9.