207987-59-5

207987-59-5 structure

Name: RS-601
Chemical Name: RS-601
CAS Number: 207987-59-5
Molecular Formula: C₂₂H₂₃F₆NO₄S
Molecular Weight: 511.478
Catalog: Signaling Pathways GPCR/G Protein Leukotriene Receptor
Create Date: 2018-05-14 07:11:45
Modify Date: 2024-01-10 20:34:25
RS-601 is a novel leukotriene D4 (LTD4)/thromboxane A2 (TxA2) dual receptor antagonist, with antiasthmatic activities.

Name	RS-601
Synonyms	4-[4-(5,5,6,6,6-Pentafluoro-1-{[(4-fluorophenyl)sulfonyl]amino}hexyl)phenyl]butanoic acid 4-(4-(5,5,6,6,6-pentafluoro-1-(4-fluorobenzene-sulfonamido)hexyl)phenyl)butyric acid Benzenebutanoic acid, 4-[5,5,6,6,6-pentafluoro-1-[[(4-fluorophenyl)sulfonyl]amino]hexyl]-

Description	RS-601 is a novel leukotriene D4 (LTD4)/thromboxane A2 (TxA2) dual receptor antagonist, with antiasthmatic activities.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Inflammation/Immunology
Target	LTD4 TXA2 Receptor
In Vivo	RS-601 (1-10 mg/kg) clearly inhibits the bronchoconstriction induced by intravenous administration of U-46619 and LTD4 in a dose-dependent fashion in guinea pigs. RS-1452 (10 mg/kg) significantly inhibits U-46619-induced bronchoconstriction, respectively. RS-601 significantly inhibits the late-phase response and LPS-induced AHR at a dose of 10 mg/kg, but does not affect biphasic bronchial responses. RS-601 (3 and 10 mg/kg) also clearly inhibits the AHR[1].
References	[1]. Yamada T, et al. Effects of RS-601, a novel leukotriene D(4)/thromboxane A(2) dual receptor antagonist, on asthmatic responses in guinea pigs. Pharmacology. 2003 Sep;69(1):51-8.