RS-601

Modify Date: 2025-08-27 09:54:55

Use of RS-601

RS-601 is a novel leukotriene D4 (LTD4)/thromboxane A2 (TxA2) dual receptor antagonist, with antiasthmatic activities.

Name	RS-601
Synonym	More Synonyms

Description	RS-601 is a novel leukotriene D4 (LTD4)/thromboxane A2 (TxA2) dual receptor antagonist, with antiasthmatic activities.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Inflammation/Immunology
Target	LTD4 TXA2 Receptor
In Vivo	RS-601 (1-10 mg/kg) clearly inhibits the bronchoconstriction induced by intravenous administration of U-46619 and LTD4 in a dose-dependent fashion in guinea pigs. RS-1452 (10 mg/kg) significantly inhibits U-46619-induced bronchoconstriction, respectively. RS-601 significantly inhibits the late-phase response and LPS-induced AHR at a dose of 10 mg/kg, but does not affect biphasic bronchial responses. RS-601 (3 and 10 mg/kg) also clearly inhibits the AHR[1].
References	[1]. Yamada T, et al. Effects of RS-601, a novel leukotriene D(4)/thromboxane A(2) dual receptor antagonist, on asthmatic responses in guinea pigs. Pharmacology. 2003 Sep;69(1):51-8.

Density	1.4±0.1 g/cm3
Boiling Point	563.3±60.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₃F₆NO₄S
Molecular Weight	511.478
Flash Point	294.5±32.9 °C
Exact Mass	511.125183
LogP	4.84
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.511
InChIKey	ZCGGCPCQTKPOSS-UHFFFAOYSA-N
SMILES	O=C(O)CCCc1ccc(C(CCCC(F)(F)C(F)(F)F)NS(=O)(=O)c2ccc(F)cc2)cc1
Storage condition	2-8℃

4-[4-(5,5,6,6,6-Pentafluoro-1-{[(4-fluorophenyl)sulfonyl]amino}hexyl)phenyl]butanoic acid

4-(4-(5,5,6,6,6-pentafluoro-1-(4-fluorobenzene-sulfonamido)hexyl)phenyl)butyric acid

Benzenebutanoic acid, 4-[5,5,6,6,6-pentafluoro-1-[[(4-fluorophenyl)sulfonyl]amino]hexyl]-

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Price: $1884/1mg

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