223568-55-6

223568-55-6 structure

Name: EP1013
Chemical Name: EP1013
CAS Number: 223568-55-6
Molecular Formula: C₁₈H₂₃FN₂O₆
Molecular Weight: 382.383
Catalog: Signaling Pathways Apoptosis Caspase
Create Date: 2018-05-19 07:39:43
Modify Date: 2024-01-13 09:57:52
EP1013 is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes.

Name	EP1013
Synonyms	Pentanoic acid, 5-fluoro-3-[[(2S)-3-methyl-1-oxo-2-[[(phenylmethoxy)carbonyl]amino]butyl]amino]-4-oxo-, (3S)- (3S)-3-({N-[(Benzyloxy)carbonyl]-L-valyl}amino)-5-fluoro-4-oxopentanoic acid

Description	EP1013 is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes.
Related Catalog	Signaling Pathways >> Apoptosis >> Caspase Research Areas >> Metabolic Disease
Target	Caspase
In Vivo	EP1013 (1, 3, 10 mg/kg) significantly improves marginal islet mass function. Two animals in the 10 mg/kg EP1013 treatment group exhibit primary islet graft nonfunction, but the diabetes reversalrate for this group is not significantly different from the 3 mg/kg EP1013, 1 mg/kg EP1013, or 10 mg/kg zVAD groups. EP1013 therapy enhances functional syngeneic islet mass and promotes longevity of islet graft function[1].
References	[1]. Emamaullee JA, et al. The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice. Diabetes. 2008 Jun;57(6):1556-66.