192819-27-5

192819-27-5 structure

Name: CDC801
Chemical Name: CDC801
CAS Number: 192819-27-5
Molecular Formula: C₂₃H₂₄N₂O₅
Molecular Weight: 408.45
Catalog: Signaling Pathways Apoptosis TNF Receptor
Create Date: 2018-04-13 16:01:56
Modify Date: 2024-01-09 08:35:37
CDC801 is a potent and orally active phosphodiesterase 4 (PDE4) and tumor necrosis factor-α (TNF-α) inhibitor with IC50 of 1.1 μM and 2.5 μM, respectively.

Name	CDC801

Description	CDC801 is a potent and orally active phosphodiesterase 4 (PDE4) and tumor necrosis factor-α (TNF-α) inhibitor with IC50 of 1.1 μM and 2.5 μM, respectively.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Signaling Pathways >> Apoptosis >> TNF Receptor Research Areas >> Cancer
Target	IC50: 1.1μM (PDE4), 2.5μM (TNF-α)[1]
In Vitro	The more detailed information refer to the Compound 6b in the reference 1 (PMID:19256507)[1].
References	[1]. Man HW, et al. Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4and tumor necrosis factor-alpha inhibitor. J Med Chem. 2009 Mar 26;52(6):1522-4.