1948273-03-7

1948273-03-7 structure

Name: E3 ligase Ligand 1
Chemical Name: E3 ligase Ligand 1
CAS Number: 1948273-03-7
Molecular Formula: C₂₃H₃₃ClN₄O₃S
Molecular Weight: 481.05
Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
Create Date: 2018-03-20 14:03:08
Modify Date: 2024-01-03 13:52:10
E3 ligase Ligand 1 is a Ligand for E3 Ligase extracted from patent WO/2017/030814A1 compound example 202, used in PROTAC technology.

Name	E3 ligase Ligand 1

Description	E3 ligase Ligand 1 is a Ligand for E3 Ligase extracted from patent WO/2017/030814A1 compound example 202, used in PROTAC technology.
Related Catalog	Signaling Pathways >> PROTAC >> Ligand for E3 Ligase Research Areas >> Cancer
Target	Ligand for E3 Ligase[1]
In Vitro	E3 ligase Ligand 1 is a VHL E3 ligase-binding ligand[1]. E3 ligase Ligand 1 is used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC. ARV-771, a small-molecule pan-BET degrader based on proteolysis-targeting chimera (PROTAC) technology, demonstrates dramatically improved efficacy in cellular models of castration-resistant prostate cancer (CRPC) as compared with BET inhibition[2].
References	[1]. WO/2017/030814A1 [2]. Kanak R, et al. PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. Proceedings of the National Academy of Sciences of the United States of America (2016), 113(26), 7124-7129