2058264-32-5
2058264-32-5 structure
- Name: TBK1/IKKε-IN-1
- Chemical Name: TBK1/IKKε-IN-1
- CAS Number: 2058264-32-5
- Molecular Formula:
- Molecular Weight: 498.53
- Catalog: Research Areas Cancer
- Create Date: 2018-06-06 07:50:25
- Modify Date: 2024-01-04 18:05:31
-
TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC50s of <100 nM.
| Name | TBK1/IKKε-IN-1 |
|---|
| Description | TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC50s of <100 nM. |
|---|---|
| Related Catalog | |
| Target |
TBK1:100 nM (IC50) IKKε:100 nM (IC50) |
| In Vitro | IKKε and TBK1 are serine/threonine kinases which are highly homologous to one another and other IkB kinases (IKK-α and IKK-β). The two kinases play an integral role in the innate immune system. Double-stranded RNA viruses are recognised by the Toll-like receptors 3 and 4 and the RNA helicases RIG-I and MDA-5 and result in activation of the TRIF-TBK1/IKKε-IRF3 signalling cascade, which results in a type I interferon response[1]. |
| References |
[1]. Brian A. Sherer, et al. Tbk/ikk inhibitor compounds and uses thereof. US 20160376283 A1. |
| Molecular Weight | 498.53 |
|---|