TBK1/IKKε-IN-1
Modify Date: 2024-01-04 18:05:31
TBK1/IKKε-IN-1 structure
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Common Name | TBK1/IKKε-IN-1 | ||
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| CAS Number | 2058264-32-5 | Molecular Weight | 498.53 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TBK1/IKKε-IN-1TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC50s of <100 nM. |
| Name | TBK1/IKKε-IN-1 |
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| Description | TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC50s of <100 nM. |
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| Related Catalog | |
| Target |
TBK1:100 nM (IC50) IKKε:100 nM (IC50) |
| In Vitro | IKKε and TBK1 are serine/threonine kinases which are highly homologous to one another and other IkB kinases (IKK-α and IKK-β). The two kinases play an integral role in the innate immune system. Double-stranded RNA viruses are recognised by the Toll-like receptors 3 and 4 and the RNA helicases RIG-I and MDA-5 and result in activation of the TRIF-TBK1/IKKε-IRF3 signalling cascade, which results in a type I interferon response[1]. |
| References |
[1]. Brian A. Sherer, et al. Tbk/ikk inhibitor compounds and uses thereof. US 20160376283 A1. |
| Molecular Weight | 498.53 |
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