2102933-95-7

2102933-95-7 structure

Name: GSK-LSD1 Dihydrochloride
Chemical Name: GSK-LSD1 Dihydrochloride
CAS Number: 2102933-95-7
Molecular Formula: C₁₄H₂₂Cl₂N₂
Molecular Weight: 289.24
Catalog: Signaling Pathways Epigenetics Histone Demethylase
Create Date: 2018-01-29 02:09:41
Modify Date: 2024-01-09 09:52:15
GSK-LSD1 Dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC50 of 16 nM.

Name	GSK-LSD1 Dihydrochloride

Description	GSK-LSD1 Dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC50 of 16 nM.
Related Catalog	Signaling Pathways >> Epigenetics >> Histone Demethylase Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Cancer
Target	IC50: 16 nM (LSD1)[1]
In Vitro	GSK-LSD1 Dihydrochloride shows more than 1000 fold selectivity over other closely related FAD utilizing enzymes including LSD2, and monoamine oxidases MAO-A, MAO-B[1]. GSK-LSD1 can inhibit KDM1A/LSD1 enzyme activity. GSK-LSD1 induces the formation of LC3-II in U2OS cells. The electronic microscopy shows the formation of autophagosome with GSK-LSD1 treatment. GSK-LSD1 potently inhibits proliferation of varies cancer cell lines by changing gene expression patterns[2].
References	[1]. Purich D. The Inhibitor Index A Desk Reference on Enzyme Inhibitors, Receptor Antagonists, Drugs, Toxins, Poisons, Biologics, and Therapeutic Leads. ISBN 9781138739215 [2]. Wang Z, et al. Inhibition of H3K4 demethylation induces autophagy in cancer cell lines. Biochim Biophys Acta. 2017 Aug 8;1864(12):2428-2437.