Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (4E)-SUN9221
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

222318-55-0

222318-55-0 structure

222318-55-0 structure

Name: (4E)-SUN9221
Chemical Name: (4E)-SUN9221
CAS Number: 222318-55-0
Molecular Formula: C₂₅H₃₁FN₄O₃
Molecular Weight: 454.54
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-03-27 14:32:41
Modify Date: 2024-01-15 00:39:54
(4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities.

Name	(4E)-SUN9221

Description	(4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease
In Vitro	(4E)-SUN9221 potently inhibits collagen-, ADP- and epinephrine-induced platelet aggregation, with IC50s of 10 nM, 35 nM, 14 nM, respectively, in human platelet-rich plasma (PRP). (4E)-SUN9221 displays potent α1-adrenergic antagonist activity (pA2 =8.89±0.21) and 5-HT2 antagonist activity (pA2 =8.74±0.22)[1].
In Vivo	(4E)-SUN9221 (1, 3, 10 mg/kg, p.o.) reduces the blood pressure in a dose-dependent manner in conscious spontaneously hypertensive rats (SHR). (4E)-SUN9221 (3 mg/kg) exhibits antihypertensive activity in SHR[1].
References	[1]. Mizuno A, et al. Synthesis and pharmacological evaluation of pyrroloazepine derivatives as potent antihypertensive agents with antiplatelet aggregation activity. Chem Pharm Bull (Tokyo). 1999 Feb;47(2):246-56.

Molecular Formula	C₂₅H₃₁FN₄O₃
Molecular Weight	454.54