1638504-66-1

1638504-66-1 structure

Name: HIV-1 integrase inhibitor 4
Chemical Name: HIV-1 integrase inhibitor 4
CAS Number: 1638504-66-1
Molecular Formula: C₂₄H₂₀F₂N₄O₅S
Molecular Weight: 514.50
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2018-04-26 07:24:03
Modify Date: 2024-01-05 16:05:06
HIV-1 integrase inhibitor 4 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 3.7 nM.

Name	HIV-1 integrase inhibitor 4

Description	HIV-1 integrase inhibitor 4 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 3.7 nM.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Integrase Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	IC50: 3.7 nM (INST)[1]
In Vitro	HIV-1 integrase inhibitor 4 (compound 4f) is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 3.7 nM. HIV-1 integrase inhibitor 4 shows potent activity against recombinant HIV IN in biochemical assays and good efficacy in assays done in cell culture against a broad panel of viral mutants carrying the major RAL and DTG IN resistance mutations[1].
References	[1]. Zhao XZ, et al. HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant MutantIntegrases. ACS Chem Biol. 2016 Apr 15;11(4):1074-81.