HIV-1 integrase inhibitor 4

Modify Date: 2025-08-25 16:39:06

HIV-1 integrase inhibitor 4 structure	Common Name	HIV-1 integrase inhibitor 4
	CAS Number	1638504-66-1	Molecular Weight	514.50
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₀F₂N₄O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HIV-1 integrase inhibitor 4

HIV-1 integrase inhibitor 4 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 3.7 nM.

Name	HIV-1 integrase inhibitor 4

Description	HIV-1 integrase inhibitor 4 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 3.7 nM.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Integrase Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	IC50: 3.7 nM (INST)[1]
In Vitro	HIV-1 integrase inhibitor 4 (compound 4f) is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 3.7 nM. HIV-1 integrase inhibitor 4 shows potent activity against recombinant HIV IN in biochemical assays and good efficacy in assays done in cell culture against a broad panel of viral mutants carrying the major RAL and DTG IN resistance mutations[1].
References	[1]. Zhao XZ, et al. HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant MutantIntegrases. ACS Chem Biol. 2016 Apr 15;11(4):1074-81.

Molecular Formula	C₂₄H₂₀F₂N₄O₅S
Molecular Weight	514.50
Storage condition	2-8℃

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