477331-06-9

477331-06-9 structure

Name: cis-ACPD
Chemical Name: (1R,3R)-1-Amino-1,3-cyclopentanedicarboxylic acid-(1S,3S)-1-amino-1,3-cyclopentanedicarboxylic acid (1:1)
CAS Number: 477331-06-9
Molecular Formula: C₁₄H₂₂N₂O₈
Molecular Weight: 346.333
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2018-06-07 22:21:47
Modify Date: 2025-09-11 11:00:15
cis-ACPD is a potent agonist of NMDA receptor, with an IC50 of 3.3 μM. And it is also a selective agonist of group II mGluR, with EC50s of 13 μM and 50 μM for mGluR2 and mGluR4, respectively[1][2].

Name	(1R,3R)-1-Amino-1,3-cyclopentanedicarboxylic acid-(1S,3S)-1-amino-1,3-cyclopentanedicarboxylic acid (1:1)
Synonyms	(1R,3R)-1-Amino-1,3-cyclopentanedicarboxylic acid - (1S,3S)-1-amino-1,3-cyclopentanedicarboxylic acid (1:1) 1,3-Cyclopentanedicarboxylic acid, 1-amino-, (1R,3R)-, compd. with (1S,3S)-1-amino-1,3-cyclopentanedicarboxylic acid (1:1)

Description	cis-ACPD is a potent agonist of NMDA receptor, with an IC50 of 3.3 μM. And it is also a selective agonist of group II mGluR, with EC50s of 13 μM and 50 μM for mGluR2 and mGluR4, respectively[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	NMDA:3.3 μM (IC50) mGluR2:13 μM (EC50) mGluR4:50 μM (EC50)
In Vitro	cis-ACPD is a selective group II mGluR agonist, with EC50s of 13, 50, >300 and >300 μM for mGluR2, mGluR4, mGluR1 and mGluR5, respectively[2]. cis-ACPD (1-1000 µM; 60 min) stimulates hydrolysis of 3H-phosphoinositide[1].
In Vivo	cis-ACPD (1-1000 mg/kg; i.p.) produces dose-related convulsions in rats[1].
References	[1]. Schoepp DD, et, al. In vitro and in vivo pharmacology of trans- and cis-(+-)-1-amino-1,3-cyclopentanedicarboxylic acid: dissociation of metabotropic and ionotropic excitatory amino acid receptor effects. J Neurochem. 1991 May; 56(5):1789-96. [2]. Conti P, et, al. Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid. Farmaco. 2002 Nov; 57(11): 889-95.