cis-ACPD
Modify Date: 2024-01-13 19:13:16
cis-ACPD structure
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Common Name | cis-ACPD | ||
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| CAS Number | 477331-06-9 | Molecular Weight | 346.333 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H22N2O8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of cis-ACPDcis-ACPD is a potent agonist of NMDA receptor, with an IC50 of 3.3 μM. And it is also a selective agonist of group II mGluR, with EC50s of 13 μM and 50 μM for mGluR2 and mGluR4, respectively[1][2]. |
| Name | (1R,3R)-1-Amino-1,3-cyclopentanedicarboxylic acid-(1S,3S)-1-amino-1,3-cyclopentanedicarboxylic acid (1:1) |
|---|---|
| Synonym | More Synonyms |
| Description | cis-ACPD is a potent agonist of NMDA receptor, with an IC50 of 3.3 μM. And it is also a selective agonist of group II mGluR, with EC50s of 13 μM and 50 μM for mGluR2 and mGluR4, respectively[1][2]. |
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| Related Catalog | |
| Target |
NMDA:3.3 μM (IC50) mGluR2:13 μM (EC50) mGluR4:50 μM (EC50) |
| In Vitro | cis-ACPD is a selective group II mGluR agonist, with EC50s of 13, 50, >300 and >300 μM for mGluR2, mGluR4, mGluR1 and mGluR5, respectively[2]. cis-ACPD (1-1000 µM; 60 min) stimulates hydrolysis of 3H-phosphoinositide[1]. |
| In Vivo | cis-ACPD (1-1000 mg/kg; i.p.) produces dose-related convulsions in rats[1]. |
| References |
| Molecular Formula | C14H22N2O8 |
|---|---|
| Molecular Weight | 346.333 |
| Exact Mass | 346.137604 |
| (1R,3R)-1-Amino-1,3-cyclopentanedicarboxylic acid - (1S,3S)-1-amino-1,3-cyclopentanedicarboxylic acid (1:1) |
| 1,3-Cyclopentanedicarboxylic acid, 1-amino-, (1R,3R)-, compd. with (1S,3S)-1-amino-1,3-cyclopentanedicarboxylic acid (1:1) |