Top Suppliers:I want be here


1245603-92-2

1245603-92-2 structure
1245603-92-2 structure
  • Name: PF 04937319
  • Chemical Name: 7E99B9ZM19
  • CAS Number: 1245603-92-2
  • Molecular Formula: C22H20N6O4
  • Molecular Weight: 432.432
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Glucokinase
  • Create Date: 2018-07-11 02:24:33
  • Modify Date: 2025-08-25 15:54:43
  • PF-04937319 is a glucokinase activator (GKA) with EC50 value of 154.4  μM, one of the most promising strategies for the treatment of type 2 diabetes mellitus[1].PF-04937319 is designed to maintain glucose-lowering efficacy while mitigating the risk of hypoglycaemia observed with many other GKAs[2].

Name 7E99B9ZM19
Synonyms 2-Pyrimidinecarboxamide, N,N-dimethyl-5-[[2-methyl-6-[[(5-methyl-2-pyrazinyl)amino]carbonyl]-4-benzofuranyl]oxy]-
N,N-Dimethyl-5-({2-Methyl-6-[(5-Methylpyrazin-2-Yl)carbamoyl]-1-Benzofuran-4-Yl}oxy)pyrimidine-2-Carboxamide
7E99B9ZM19
N,N-Dimethyl-5-({2-methyl-6-[(5-methyl-2-pyrazinyl)carbamoyl]-1-benzofuran-4-yl}oxy)-2-pyrimidinecarboxamide
PF-04937319
Description PF-04937319 is a glucokinase activator (GKA) with EC50 value of 154.4  μM, one of the most promising strategies for the treatment of type 2 diabetes mellitus[1].PF-04937319 is designed to maintain glucose-lowering efficacy while mitigating the risk of hypoglycaemia observed with many other GKAs[2].
Related Catalog
Target

EC50: 154.4 μM (GSA) (PF-04937319)[1]

References

[1]. Dzyurkevich MS, et al. Pyridoxine dipharmacophore derivatives as potent glucokinase activators for the treatment of type 2 diabetes mellitus. Sci Rep. 2017 Nov 22;7(1):16072.

[2]. Amin NB, et al. Two dose-ranging studies with PF-04937319, a systemic partial activator of glucokinase, as add-on therapy to metformin in adults with type 2 diabetes. Diabetes Obes Metab. 2015 Aug;17(8):751-9.

Density 1.4±0.1 g/cm3
Molecular Formula C22H20N6O4
Molecular Weight 432.432
Exact Mass 432.154602
LogP 1.29
Index of Refraction 1.667
RIDADR NONH for all modes of transport
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.