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1268244-85-4

1268244-85-4 structure
1268244-85-4 structure
  • Name: PX20606 trans racemate
  • Chemical Name: 378SU5NO8S
  • CAS Number: 1268244-85-4
  • Molecular Formula: C29H22Cl3NO4
  • Molecular Weight: 554.85
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease FXR
  • Create Date: 2018-06-09 09:09:08
  • Modify Date: 2024-01-14 11:06:39
  • PX20606 trans racemate is a FXR agonist with EC50s of 32 and 34 nM for FXR in FRET and M1H assay, respectively.

Name 378SU5NO8S
Synonyms 6TU6SUZ3BY
UNII:6TU6SUZ3BY
UNII:378SU5NO8S
Benzoic acid, 4-[(1S,2S)-2-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]phenyl]cyclopropyl]-
4-[(1S,2S)-2-(2-Chloro-4-{[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy}phenyl)cyclopropyl]benzoic acid
378SU5NO8S
PX20606 trans racemate
Description PX20606 trans racemate is a FXR agonist with EC50s of 32 and 34 nM for FXR in FRET and M1H assay, respectively.
Related Catalog
Target

EC50: 32 nM (FXR in FRET assay), 34 nM (FXR in M1H assay)[1]

References

[1]. Kinzel O, et al. Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3746-53.

Molecular Formula C29H22Cl3NO4
Molecular Weight 554.85
Storage condition 2-8℃