1268244-85-4

1268244-85-4 structure

Name: PX20606 trans racemate
Chemical Name: 378SU5NO8S
CAS Number: 1268244-85-4
Molecular Formula: C₂₉H₂₂Cl₃NO₄
Molecular Weight: 554.85
Catalog: Signaling Pathways Metabolic Enzyme/Protease FXR
Create Date: 2018-06-09 09:09:08
Modify Date: 2024-01-14 11:06:39
PX20606 trans racemate is a FXR agonist with EC50s of 32 and 34 nM for FXR in FRET and M1H assay, respectively.

Name	378SU5NO8S
Synonyms	6TU6SUZ3BY UNII:6TU6SUZ3BY UNII:378SU5NO8S Benzoic acid, 4-[(1S,2S)-2-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]phenyl]cyclopropyl]- 4-[(1S,2S)-2-(2-Chloro-4-{[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy}phenyl)cyclopropyl]benzoic acid 378SU5NO8S PX20606 trans racemate

Description	PX20606 trans racemate is a FXR agonist with EC50s of 32 and 34 nM for FXR in FRET and M1H assay, respectively.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> FXR Research Areas >> Metabolic Disease
Target	EC50: 32 nM (FXR in FRET assay), 34 nM (FXR in M1H assay)[1]
References	[1]. Kinzel O, et al. Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3746-53.