1247847-78-4

1247847-78-4 structure

Name: Simmitecan hydrochloride
Chemical Name: T4H02O147G
CAS Number: 1247847-78-4
Molecular Formula: C₃₄H₃₉ClN₄O₆
Molecular Weight: 635.150
Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
Create Date: 2018-06-18 19:49:16
Modify Date: 2024-01-28 16:10:20
Simmitecan hydrochloride, a 9-substituted lipophilic Camptothecin (HY-16560) derivative, is a potent topoisomerase I inhibitor. Simmitecan hydrochloride is an anticancer agent[1][2].

Name	T4H02O147G
Synonyms	(4S)-10-Allyl-4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 1,4'-bipiperidine-1'-carboxylate hydrochloride (1:1) [1,4'-Bipiperidine]-1'-carboxylic acid, (4S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-10-(2-propen-1-yl)-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester, hydrochloride (1:1) Simmitecan hydrochloride Simmitecan hydrochloride salt T4H02O147G

Description	Simmitecan hydrochloride, a 9-substituted lipophilic Camptothecin (HY-16560) derivative, is a potent topoisomerase I inhibitor. Simmitecan hydrochloride is an anticancer agent[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
In Vitro	Simmitecan hydrochloride 对 CYP2D6 有弱抑制作用 (IC50: 32.9 μM)，对 CYP3A4 有中等抑制作用 (IC50: 8.95 μM)[2]。
In Vivo	Simmitecan hydrochloride (3.75、7.5 和 15 mg/kg, SD 大鼠, 静脉推注) 显示平均消除半衰期 t1/2 约为 1.4 小时[2]。
References	[1]. Rini B, et al. A phase I/II study of lenalidomide in combination with sunitinib in patients with advanced or metastatic renal cell carcinoma. Ann Oncol. 2014 Sep;25(9):1794-1799. [2]. Hu ZY, et al. Pharmacokinetic evaluation of the anticancer prodrug simmitecan in different experimental animals. Acta Pharmacol Sin. 2013 Nov;34(11):1437-48.