Simmitecan hydrochloride
Modify Date: 2024-01-28 16:10:20
Simmitecan hydrochloride structure
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Common Name | Simmitecan hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1247847-78-4 | Molecular Weight | 635.150 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C34H39ClN4O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Simmitecan hydrochlorideSimmitecan hydrochloride, a 9-substituted lipophilic Camptothecin (HY-16560) derivative, is a potent topoisomerase I inhibitor. Simmitecan hydrochloride is an anticancer agent[1][2]. |
| Name | T4H02O147G |
|---|---|
| Synonym | More Synonyms |
| Description | Simmitecan hydrochloride, a 9-substituted lipophilic Camptothecin (HY-16560) derivative, is a potent topoisomerase I inhibitor. Simmitecan hydrochloride is an anticancer agent[1][2]. |
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| Related Catalog | |
| In Vitro | Simmitecan hydrochloride 对 CYP2D6 有弱抑制作用 (IC50: 32.9 μM)，对 CYP3A4 有中等抑制作用 (IC50: 8.95 μM)[2]。 |
| In Vivo | Simmitecan hydrochloride (3.75、7.5 和 15 mg/kg, SD 大鼠, 静脉推注) 显示平均消除半衰期 t1/2 约为 1.4 小时[2]。 |
| References |
| Molecular Formula | C34H39ClN4O6 |
|---|---|
| Molecular Weight | 635.150 |
| Exact Mass | 634.255798 |
| (4S)-10-Allyl-4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 1,4'-bipiperidine-1'-carboxylate hydrochloride (1:1) |
| [1,4'-Bipiperidine]-1'-carboxylic acid, (4S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-10-(2-propen-1-yl)-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester, hydrochloride (1:1) |
| Simmitecan hydrochloride |
| Simmitecan hydrochloride salt |
| T4H02O147G |