1523437-16-2

1523437-16-2 structure

Name: N-{4-[(4-Chloro-1-piperidinyl)sulfonyl]phenyl}-5-nitro-2-furamide
Chemical Name: N-{4-[(4-Chloro-1-piperidinyl)sulfonyl]phenyl}-5-nitro-2-furamide
CAS Number: 1523437-16-2
Molecular Formula: C₁₆H₁₆ClN₃O₆S
Molecular Weight: 413.83
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-06-27 15:16:17
Modify Date: 2024-01-06 18:20:29
ML291 is a UPR (unfolded protein response)-inducing sulfonamidebenzamide. ML291 overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models. ML291 can activate the PERK/eIF2a/CHOP (apoptotic) arm of the UPR and reduce leukemic cell burden[1].

Name	N-{4-[(4-Chloro-1-piperidinyl)sulfonyl]phenyl}-5-nitro-2-furamide
Synonyms	N-{4-[(4-Chloro-1-piperidinyl)sulfonyl]phenyl}-5-nitro-2-furamide 2-Furancarboxamide, N-[4-[(4-chloro-1-piperidinyl)sulfonyl]phenyl]-5-nitro-

Description	ML291 is a UPR (unfolded protein response)-inducing sulfonamidebenzamide. ML291 overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models. ML291 can activate the PERK/eIF2a/CHOP (apoptotic) arm of the UPR and reduce leukemic cell burden[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF) Signaling Pathways >> Cell Cycle/DNA Damage >> PERK
References	[1]. Danielle Garshott, et al. The Novel Sulfonamidebenzamide ML291 Activates Apoptotic UPR Signaling in Pediatric Leukemia. Blood. 2016,128(22):3523.

RIDADR	NONH for all modes of transport