N-{4-[(4-Chloro-1-piperidinyl)sulfonyl]phenyl}-5-nitro-2-furamide

Modify Date: 2024-01-06 18:20:29

N-{4-[(4-Chloro-1-piperidinyl)sulfonyl]phenyl}-5-nitro-2-furamide structure	Common Name	N-{4-[(4-Chloro-1-piperidinyl)sulfonyl]phenyl}-5-nitro-2-furamide
	CAS Number	1523437-16-2	Molecular Weight	413.83
	Density	1.6±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₆ClN₃O₆S	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of N-{4-[(4-Chloro-1-piperidinyl)sulfonyl]phenyl}-5-nitro-2-furamide

ML291 is a UPR (unfolded protein response)-inducing sulfonamidebenzamide. ML291 overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models. ML291 can activate the PERK/eIF2a/CHOP (apoptotic) arm of the UPR and reduce leukemic cell burden[1].

Name	N-{4-[(4-Chloro-1-piperidinyl)sulfonyl]phenyl}-5-nitro-2-furamide
Synonym	More Synonyms

Description	ML291 is a UPR (unfolded protein response)-inducing sulfonamidebenzamide. ML291 overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models. ML291 can activate the PERK/eIF2a/CHOP (apoptotic) arm of the UPR and reduce leukemic cell burden[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF) Signaling Pathways >> Cell Cycle/DNA Damage >> PERK
References	[1]. Danielle Garshott, et al. The Novel Sulfonamidebenzamide ML291 Activates Apoptotic UPR Signaling in Pediatric Leukemia. Blood. 2016,128(22):3523.

Density	1.6±0.1 g/cm3
Molecular Formula	C₁₆H₁₆ClN₃O₆S
Molecular Weight	413.83
Exact Mass	413.044830
LogP	2.78
Index of Refraction	1.652

RIDADR	NONH for all modes of transport

N-{4-[(4-Chloro-1-piperidinyl)sulfonyl]phenyl}-5-nitro-2-furamide

2-Furancarboxamide, N-[4-[(4-chloro-1-piperidinyl)sulfonyl]phenyl]-5-nitro-

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: N-{4-[(4-Chloro-1-piperidinyl)sulfonyl]phenyl}-5-nitro-2-furamide
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: ML291
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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N-{4-[(4-Chloro-1-piperidinyl)sulfonyl]phenyl}-5-nitro-2-furamide

Use of N-{4-[(4-Chloro-1-piperidinyl)sulfonyl]phenyl}-5-nitro-2-furamide

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.