792946-69-1

792946-69-1 structure

Name: DCLX069
Chemical Name: Ethyl 3-amino-4-(4-benzyl-1-piperazinyl)benzoate
CAS Number: 792946-69-1
Molecular Formula: C₂₀H₂₅N₃O₂
Molecular Weight: 339.431
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2018-06-16 14:58:13
Modify Date: 2024-01-17 22:59:44
DCLX069 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 value of 17.9 µM. DCLX069 shows less active against PRMT4 and PRMT6. DCLX069 has anticancer effects[1].

Name	Ethyl 3-amino-4-(4-benzyl-1-piperazinyl)benzoate
Synonyms	MFCD06666140 Benzoic acid, 3-amino-4-[4-(phenylmethyl)-1-piperazinyl]-, ethyl ester Ethyl 3-amino-4-(4-benzyl-1-piperazinyl)benzoate

Description	DCLX069 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 value of 17.9 µM. DCLX069 shows less active against PRMT4 and PRMT6. DCLX069 has anticancer effects[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase
Target	PRMT1:17.9 μM (IC50)
In Vitro	DCLX069 (12.5-100 µM) effectively blocks cell proliferation in breast cancer, liver cancer and acute myeloid leukemia cell lines (MCF7, HepG2, and THP1 cells) in a concentration-dependent manner[1].
References	[1]. Yiqian Xie, et al. Virtual screening and biological evaluation of novel small molecular inhibitors against protein arginine methyltransferase 1 (PRMT1). Org Biomol Chem. 2014 Dec 21;12(47):9665-73.