1133210-23-7

1133210-23-7 structure

Name: Levocetirizine-d4
Chemical Name: {[2-{4-[(R)-(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl}(2H4)ethyl]oxy}acetic acid
CAS Number: 1133210-23-7
Molecular Formula: C₂₁H₂₁D₄ClN₂O₃
Molecular Weight: 392.91
Create Date: 2018-07-03 04:42:44
Modify Date: 2024-01-10 13:47:38
Levocetirizine-d4 ((R)-Cetirizine-d4) is the deuterium-labeled Levocetirizine (HY-B0814)[1]. Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[2].

Name	{[2-{4-[(R)-(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl}(2H4)ethyl]oxy}acetic acid
Synonyms	Acetic acid, 2-[[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethyl-1,1,2,2-d4]oxy]- {[2-{4-[(R)-(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl}(2H4)ethyl]oxy}acetic acid

Description	Levocetirizine-d4 ((R)-Cetirizine-d4) is the deuterium-labeled Levocetirizine (HY-B0814)[1]. Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[2].
Related Catalog	Research Areas >> Inflammation/Immunology
In Vitro	氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.