Levocetirizine-d4
Modify Date: 2024-01-10 13:47:38
Levocetirizine-d4 structure
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Common Name | Levocetirizine-d4 | ||
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| CAS Number | 1133210-23-7 | Molecular Weight | 392.91 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 542.1±45.0 °C at 760 mmHg | |
| Molecular Formula | C21H21D4ClN2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 281.6±28.7 °C | |
Use of Levocetirizine-d4Levocetirizine-d4 ((R)-Cetirizine-d4) is the deuterium-labeled Levocetirizine (HY-B0814)[1]. Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[2]. |
| Name | {[2-{4-[(R)-(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl}(2H4)ethyl]oxy}acetic acid |
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| Synonym | More Synonyms |
| Description | Levocetirizine-d4 ((R)-Cetirizine-d4) is the deuterium-labeled Levocetirizine (HY-B0814)[1]. Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[2]. |
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| Related Catalog | |
| In Vitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。 |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 542.1±45.0 °C at 760 mmHg |
| Molecular Formula | C21H21D4ClN2O3 |
| Molecular Weight | 392.91 |
| Flash Point | 281.6±28.7 °C |
| Exact Mass | 392.180481 |
| LogP | 2.16 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.589 |
| Acetic acid, 2-[[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethyl-1,1,2,2-d4]oxy]- |
| {[2-{4-[(R)-(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl}(2H4)ethyl]oxy}acetic acid |