174262-13-6

174262-13-6 structure

Name: SDZ285428
Chemical Name: 4'-Chloro-N-[2-(1H-imidazol-1-yl)-2-phenylethyl]-4-biphenylcarboxamide
CAS Number: 174262-13-6
Molecular Formula: C₂₄H₂₀ClN₃O
Molecular Weight: 401.888
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2018-06-15 19:36:44
Modify Date: 2024-01-10 02:47:05
SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h)[1].

Name	4'-Chloro-N-[2-(1H-imidazol-1-yl)-2-phenylethyl]-4-biphenylcarboxamide
Synonyms	4'-chloro-N-[2-(1H-imidazol-1-yl)-2-phenylethyl]biphenyl-4-carboxamide 4'-Chloro-N-[2-(1H-imidazol-1-yl)-2-phenylethyl]-4-biphenylcarboxamide [1,1'-Biphenyl]-4-carboxamide, 4'-chloro-N-[2-(1H-imidazol-1-yl)-2-phenylethyl]-

Description	SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h)[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Signaling Pathways >> Anti-infection >> Fungal
Target	CYP51
In Vivo	Specific inhibition of protozoan CYP51 can potentially provide treatment for human trypanosomiases[1].
References	[1]. Lepesheva GI, et al. CYP51: A major drug target in the cytochrome P450 superfamily. Lipids. 2008 Dec;43(12):1117-25.