1261393-15-0

1261393-15-0 structure

Name: Apixaban-13C,d3
Chemical Name: 1-{4-[(13C,2H3)Methyloxy]phenyl}-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
CAS Number: 1261393-15-0
Molecular Formula: C₂₄₁₃CH₂₂D₃N₅O₄
Molecular Weight: 463.508
Catalog: Signaling Pathways Metabolic Enzyme/Protease Factor Xa
Create Date: 2018-06-17 04:32:18
Modify Date: 2024-01-16 08:45:58
Apixaban 13CD3 (BMS-562247-01 13CD3) is a deuterium labeled Apixaban. Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[1].

Name	1-{4-[(13C,2H3)Methyloxy]phenyl}-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
Synonyms	1-{4-[(13C,2H3)Methyloxy]phenyl}-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide 1H-Pyrazolo[3,4-c]pyridine-3-carboxamide, 4,5,6,7-tetrahydro-1-[4-(methyl-13C-d3-oxy)phenyl]-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-

Description	Apixaban 13CD3 (BMS-562247-01 13CD3) is a deuterium labeled Apixaban. Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa
References	[1]. Pinto DJ, et al. Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa. J Med Chem. 2007 Nov 1;50(22):5339-56.

Hazard Codes	Xi