1448009-94-6

1448009-94-6 structure

Name: CS-1
Chemical Name: 4-(6-Hydroxy-2-naphthyl)-1,2-benzenediol
CAS Number: 1448009-94-6
Molecular Formula: C₁₆H₁₂O₃
Molecular Weight: 252.265
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-07-14 18:54:07
Modify Date: 2024-01-02 13:48:55
CS1 is a potent DNA Topo II α inhibitor. CS1 displays broad-spectrum in vitro antitumor effects, low toxicity in vivo and potential anti-multidrug resistance capabilities. CS1 leads to DNA damage, cell cycle arrest at G2/M phase and apoptosis[1].

Name	4-(6-Hydroxy-2-naphthyl)-1,2-benzenediol
Synonyms	1,2-Benzenediol, 4-(6-hydroxy-2-naphthalenyl)- 4-(6-Hydroxy-2-naphthyl)-1,2-benzenediol

Description	CS1 is a potent DNA Topo II α inhibitor. CS1 displays broad-spectrum in vitro antitumor effects, low toxicity in vivo and potential anti-multidrug resistance capabilities. CS1 leads to DNA damage, cell cycle arrest at G2/M phase and apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	topoisomerase II alpha
In Vitro	CS1 shows cytotoxicity with IC50 values of 16.92 and 18.88 µM for MCF-7 and MCF7/ADR cells, respectively[1] . CS1 (10, 50, 100 µM) inhibits the activity of topoisomerase II α (Topo IIα)[1]. CS1 (0-20 µM) shows antiproliferation activity in cancer cells[1]. CS1 (2.5, 5, 10 µM) induces cell cycle arrest at the G2/M phase[1]. CS1 (2.5, 5, 10 µM) induces cell apoptosis[1]. CS1 (5, 10, 15 µM; 24 h) induces DNA breaks in MDA-MB-231 cells[1]. Cell Cycle Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 2.5, 5, 10 µM Incubation Time: Result: Cells were arrest at the G2/M phase. Apoptosis Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 2.5, 5, 10 µM Incubation Time: Result: Induced apoptosis
In Vivo	CS1 (20 mg/kg; i.v.; every other day for two weeks) shows antitumor effects[1]. Animal Model: Five-week-old female athymic nude mice (BALB/c-nu)[1] Dosage: 20 mg/kg Administration: i.v., every other day for two weeks Result: Showed antitumor effects.
References	[1]. Shen Y, et al. CS1 is a novel topoisomerase IIα inhibitor with favorable drug resistance profiles. Biochem Biophys Res Commun. 2014; 453(3):302-8.

Density	1.4±0.1 g/cm3
Boiling Point	508.8±45.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₂O₃
Molecular Weight	252.265
Flash Point	251.3±23.3 °C
Exact Mass	252.078644
LogP	3.08
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.741

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H315-H319-H335-H400
Precautionary Statements	P305 + P351 + P338
RIDADR	UN 3077 9 / PGIII

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