1448009-94-6
1448009-94-6 structure
- Name: CS-1
- Chemical Name: 4-(6-Hydroxy-2-naphthyl)-1,2-benzenediol
- CAS Number: 1448009-94-6
- Molecular Formula: C16H12O3
- Molecular Weight: 252.265
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-07-14 18:54:07
- Modify Date: 2024-01-02 13:48:55
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CS1 is a potent DNA Topo II α inhibitor. CS1 displays broad-spectrum in vitro antitumor effects, low toxicity in vivo and potential anti-multidrug resistance capabilities. CS1 leads to DNA damage, cell cycle arrest at G2/M phase and apoptosis[1].
| Name | 4-(6-Hydroxy-2-naphthyl)-1,2-benzenediol |
|---|---|
| Synonyms |
1,2-Benzenediol, 4-(6-hydroxy-2-naphthalenyl)-
4-(6-Hydroxy-2-naphthyl)-1,2-benzenediol |
| Description | CS1 is a potent DNA Topo II α inhibitor. CS1 displays broad-spectrum in vitro antitumor effects, low toxicity in vivo and potential anti-multidrug resistance capabilities. CS1 leads to DNA damage, cell cycle arrest at G2/M phase and apoptosis[1]. |
|---|---|
| Related Catalog | |
| Target |
topoisomerase II alpha |
| In Vitro | CS1 shows cytotoxicity with IC50 values of 16.92 and 18.88 µM for MCF-7 and MCF7/ADR cells, respectively[1] . CS1 (10, 50, 100 µM) inhibits the activity of topoisomerase II α (Topo IIα)[1]. CS1 (0-20 µM) shows antiproliferation activity in cancer cells[1]. CS1 (2.5, 5, 10 µM) induces cell cycle arrest at the G2/M phase[1]. CS1 (2.5, 5, 10 µM) induces cell apoptosis[1]. CS1 (5, 10, 15 µM; 24 h) induces DNA breaks in MDA-MB-231 cells[1]. Cell Cycle Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 2.5, 5, 10 µM Incubation Time: Result: Cells were arrest at the G2/M phase. Apoptosis Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 2.5, 5, 10 µM Incubation Time: Result: Induced apoptosis |
| In Vivo | CS1 (20 mg/kg; i.v.; every other day for two weeks) shows antitumor effects[1]. Animal Model: Five-week-old female athymic nude mice (BALB/c-nu)[1] Dosage: 20 mg/kg Administration: i.v., every other day for two weeks Result: Showed antitumor effects. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 508.8±45.0 °C at 760 mmHg |
| Molecular Formula | C16H12O3 |
| Molecular Weight | 252.265 |
| Flash Point | 251.3±23.3 °C |
| Exact Mass | 252.078644 |
| LogP | 3.08 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.741 |
| Symbol |
GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335-H400 |
| Precautionary Statements | P305 + P351 + P338 |
| RIDADR | UN 3077 9 / PGIII |