348148-51-6

348148-51-6 structure

Name: Ceefourin 2
Chemical Name: 3-Chloro-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid
CAS Number: 348148-51-6
Molecular Formula: C₁₅H₉ClF₃N₃O₂
Molecular Weight: 355.70
Catalog: Research Areas Others
Create Date: 2018-06-16 09:36:58
Modify Date: 2024-01-05 15:50:17
Ceefourin 2 is a potent and highly selective inhibitor of MRP4. Ceefourin 2 inhibits the transport of MRP4 substrates but is not selective for other ABC transporters. Ceefourin 2 shows lower cytotoxicity and higher microsomal and acid stability[1].

Name	3-Chloro-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid
Synonyms	3-Chloro-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid Pyrazolo[1,5-a]pyrimidine-2-carboxylic acid, 3-chloro-5-(4-methylphenyl)-7-(trifluoromethyl)-

Description	Ceefourin 2 is a potent and highly selective inhibitor of MRP4. Ceefourin 2 inhibits the transport of MRP4 substrates but is not selective for other ABC transporters. Ceefourin 2 shows lower cytotoxicity and higher microsomal and acid stability[1].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Cheung L, et al. High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4). Biochem Pharmacol. 2014 Sep 1;91(1):97-108.