Ceefourin 2

Modify Date: 2024-01-05 15:50:17

Ceefourin 2 Structure
Ceefourin 2 structure
Common Name Ceefourin 2
CAS Number 348148-51-6 Molecular Weight 355.70
Density 1.6±0.1 g/cm3 Boiling Point N/A
Molecular Formula C15H9ClF3N3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Ceefourin 2


Ceefourin 2 is a potent and highly selective inhibitor of MRP4. Ceefourin 2 inhibits the transport of MRP4 substrates but is not selective for other ABC transporters. Ceefourin 2 shows lower cytotoxicity and higher microsomal and acid stability[1].

 Names

Name 3-Chloro-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid
Synonym More Synonyms

 Ceefourin 2 Biological Activity

Description Ceefourin 2 is a potent and highly selective inhibitor of MRP4. Ceefourin 2 inhibits the transport of MRP4 substrates but is not selective for other ABC transporters. Ceefourin 2 shows lower cytotoxicity and higher microsomal and acid stability[1].
Related Catalog
References

[1]. Cheung L, et al. High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4). Biochem Pharmacol. 2014 Sep 1;91(1):97-108.  

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Molecular Formula C15H9ClF3N3O2
Molecular Weight 355.70
Exact Mass 355.033539
LogP 3.03
Index of Refraction 1.630

 Synonyms

3-Chloro-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid
Pyrazolo[1,5-a]pyrimidine-2-carboxylic acid, 3-chloro-5-(4-methylphenyl)-7-(trifluoromethyl)-