618860-58-5

618860-58-5 structure

Name: Vernolide B
Chemical Name: (1R,2E,8S,10R,11S)-6-(Acetoxymethyl)-11-methoxy-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.03,7]tetradeca-2,6-dien-8-yl (2E)-2-methyl-2-butenoate
CAS Number: 618860-58-5
Molecular Formula: C₂₃H₃₀O₈
Molecular Weight: 434.48
Catalog: Natural product Sesquiter
Create Date: 2018-07-07 14:59:55
Modify Date: 2024-07-05 20:52:17
Vernolide-B has cytoxicity (ED50s: 3.78, 5.88, 6.42 μg/mL for KB, NCI-661, and HeLa cells respectively). Vernolide B is sesquiterpene lactone that can be isolated from Vernonia cinerea[1].

Name	(1R,2E,8S,10R,11S)-6-(Acetoxymethyl)-11-methoxy-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.03,7]tetradeca-2,6-dien-8-yl (2E)-2-methyl-2-butenoate
Synonyms	2-Butenoic acid, 2-methyl-, (4S,6R,7S,10R,11E)-3-[(acetyloxy)methyl]-2,4,5,6,7,8,9,10-octahydro-7-methoxy-6,10-dimethyl-2-oxo-7,10-epoxycyclodeca[b]furan-4-yl ester, (2E)- (1R,2E,8S,10R,11S)-6-(Acetoxymethyl)-11-methoxy-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.03,7]tetradeca-2,6-dien-8-yl (2E)-2-methyl-2-butenoate

Description	Vernolide-B has cytoxicity (ED50s: 3.78, 5.88, 6.42 μg/mL for KB, NCI-661, and HeLa cells respectively). Vernolide B is sesquiterpene lactone that can be isolated from Vernonia cinerea[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Kuo YH, et al. Two novel sesquiterpene lactones, cytotoxic vernolide-A and -B, from Vernonia cinerea. Chem Pharm Bull (Tokyo). 2003 Apr;51(4):425-6.